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Carcinogenesis Within a life span carcinogenicity review carried out in B6C3F1 mice, methylphenidate caused an increase in hepatocellular adenomas, and in males only, an increase in hepatoblastomas in a each day dose of about sixty mg/kg/working day. This dose is around two times the MRHD of 60 mg/day given to little ones on mg/m2 foundation.In-par